¶ Deliveries with discharge dates during March 2020–September 2021 were included. Implementing evidence-based COVID-19 prevention strategies, including vaccination before or during pregnancy, is critical to reducing the impact of COVID-19 on stillbirths.ĭelivery hospitalizations were identified from PHD-SR using International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) diagnostic and procedure codes pertaining to obstetric delivery and diagnosis-related group delivery codes. COVID-19 documented at delivery was associated with increased risk for stillbirth, with a stronger association during the period of Delta variant predominance. The adjusted risk for stillbirth was higher in deliveries with COVID-19 compared with deliveries without COVID-19 during March 2020–September 2021 (adjusted relative risk = 1.90 95% CI = 1.69–2.15), including during the pre-Delta (aRR = 1.47 95% CI = 1.27–1.71) and Delta periods (aRR = 4.04 95% CI = 3.28–4.97). Among 1,249,634 deliveries during March 2020–September 2021, stillbirths were rare (8,154 0.65%): 273 (1.26%) occurred among 21,653 deliveries to women with COVID-19 documented at the delivery hospitalization, and 7,881 (0.64%) occurred among 1,227,981 deliveries without COVID-19. † CDC used the Premier Healthcare Database Special COVID-19 Release (PHD-SR), a large hospital-based administrative database, § to assess whether a maternal COVID-19 diagnosis documented at delivery hospitalization was associated with stillbirth during March 2020 –September 2021 as well as before and during the period of Delta variant predominance in the United States (March 2020 –June 2021 and July–September 2021, respectively). Since the B.1.617.2 (Delta) variant of SARS-CoV-2 (the virus that causes COVID-19) became the predominant circulating variant,* there have been anecdotal reports of increasing rates of stillbirths in women with COVID-19. To date, studies assessing whether COVID-19 during pregnancy is associated with increased risk for stillbirth have yielded mixed results ( 2– 4). Pregnant women are at increased risk for severe COVID-19–related illness, and COVID-19 is associated with an increased risk for adverse pregnancy outcomes and maternal and neonatal complications ( 1– 3).
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